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GYM CONQUER ジム筋華のブランドイメージ

Dramatic Improvement! New Approach to Insulin Resistance

Yare yare daze! Astonishing new facts about improving insulin resistance have emerged. We now understand that many lifestyle diseases stem from inflammation, and insulin resistance is a key factor. A groundbreaking approach to tackling this issue has been discovered!

A visual explanation of improving insulin resistance in Jotaro Kujo's style, featuring his hat and coat, Stand, insulin action within cells, obesity and inflammation icons, a dynamic background, and the onomatopoeia 'ゴゴゴゴ' and 'ドドドド'.

The Mechanism of Insulin Action

First, let's review how insulin works in the body. Pancreatic β-cells contain a transporter called GLUT2, which helps glucose enter the cells. When glucose is converted to ATP, ATP-sensitive K+ channels close, causing depolarization. This triggers the opening of Ca2+ channels, leading to insulin secretion. This insulin binds to insulin receptors on cell surfaces, initiating a cascade of reactions.

Causes of Insulin Resistance

One major cause of insulin resistance is obesity. Visceral fat secretes cytokines like TNF-α and resistin, along with free fatty acids, which disrupt insulin signaling and lead to insulin resistance.

Methods to Improve Insulin Resistance

Improving insulin resistance requires boosting the secretion of adiponectin, which activates AMPK and promotes GLUT4 translocation. Supplements like EPA, arginine, corosolic acid, alpha-lipoic acid, zinc, and chromium have shown effectiveness in this regard.

New Discovery: Nitrosylation

Recent studies have identified that insulin β-receptors and IRS complexes are nitrosylated by a molecule called SCAN, leading to insulin resistance. Nitrosylation is a modification of proteins by reactive nitrogen species, and its increase in obese and high-fat diet mice confirms its role in insulin resistance.

New Approaches to Insulin Resistance

To counteract this, EGCG, quercetin, ginger, astaxanthin, and hydrogen can be effective. These compounds can help reduce the problem of reactive nitrogen species, thus potentially improving insulin resistance.



Improving insulin resistance involves promoting adiponectin secretion through specific foods and supplements, incorporating regular exercise, and preventing nitrosylation. Yare yare daze, the battle against insulin resistance continues, but new discoveries and approaches will help safeguard our health.


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