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GYM CONQUER ジム筋華のブランドイメージ

A Fierce Battle! The Intense Relationship Between Cancer and Glutamine



"Yare yare daze..." Unraveling the terrifying secrets of cancer cells! Exposing the insane metabolic mechanisms at play!!

A dramatic illustration of a brave warrior cell in the style of Jotaro Kujo battling cancer cells using glutamine. The warrior wields a glowing sword labeled 'Glutamine' and fights against a multi-headed monster-like cancer cell. The background features a dark, stormy sky symbolizing the intense battle.

The Dark Side of Glucose: Glycolysis and the TCA Cycle

Cancer cells are infamous for using glucose as their primary nutrient source. This process, known as glycolysis, breaks down glucose into pyruvate. In normal cells, this pyruvate enters the TCA cycle (Krebs cycle) and oxidative phosphorylation, eventually being converted into carbon dioxide and water. However, cancer cells halt at glycolysis! Why? To avoid the reactive oxygen species (ROS) generated by oxidative phosphorylation, protecting themselves from oxidative damage.


The Second Battlefield: Utilizing Glutamine

But cancer cells don't stop there. They're relentless warriors that refuse to starve. When glucose is scarce, they turn to glutamine. This amino acid becomes their alternative energy source. The enzyme phosphoenolpyruvate carboxykinase (PCK2) assists in this process. Glutamine is converted into phosphoenolpyruvate, aiding in the synthesis of essential molecules like serine and purines.


The Reverse TCA Cycle: An Astonishing Revelation

Moreover, in cancer cells, the TCA cycle can run in reverse—a shocking revelation. Glutamine-derived α-ketoglutarate converts into isocitrate and then into citrate, producing acetyl-CoA. This mechanism allows cancer cells to secure a new energy source and continue their proliferation.


The Effects of Glutamine Supplementation

But what about glutamine supplementation? Surprising experimental results show that supplementing rats with glutamine reduced tumor growth by 40% within three weeks. Additionally, glutamine increased natural killer cell activity, inhibiting tumor growth. This suggests that glutamine supplementation could play a role in cancer treatment.

Recent research also revealed that cancer cells acquire resistance to nutrient deprivation when glutamine is scarce. This resistance can be mitigated when glutamine is sufficiently available.


Chemotherapy and surgeries often reduce immune function and disrupt gut health. Glutamine supplementation can enhance immune function and promote wound healing, maintaining overall strength and health.


 

Conclusion

The relationship between cancer and glutamine is indeed an intense battle. By understanding this mechanism, we can devise new strategies in the fight against cancer. Trust in the power of glutamine and forge a new path to conquer cancer cells!



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